NAT3 allele (haplotype)(a) |
Nucleotide
change(s)(b) |
Amino
acid change(s)(b) |
Organism |
Literature |
(MOUSE)Nat3*1 |
Reference |
Reference |
Mouse |
|
(MUSMC)Nat3*2 |
238G>A |
A80T |
Mouse |
|
(MUSSP)Nat3*3 |
147A>G |
Synonymous Synonymous A80T
|
Mouse |
|
(RAT)Nat3*1 |
Reference |
Reference |
Rat |
|
(RAT)Nat3*2 |
619G>T |
A207S |
Rat |
(a)
The gene symbols are assigned according to the current guidelines
of the NAT Gene Nomenclature Committee [1]. The
alleles of rodents are written as Nat (first letter uppercase and second
and third letter lowercase). The alleles of all other species are all uppercase
(e.g. NAT).
(b)
The position of SNPs in each
ORF is determined relative to the A of the ATG translation initiation codon,
which is always considered as number 1. The first methionine of each NAT
protein is amino acid number 1, with polymorphic amino acid positions
determined accordingly. The reference allele of each NAT3 gene (usually
the wild type allele or the first allele identified in a specific organism) is
assigned symbol NAT3*1.
(c)
Studied western European
house mouse (Mus musculus
domesticus) laboratory strains: i) inbred C57Bl/6J [2-5], Balb/c [2], C3H/HeJ [3], 129/Ola [4], CBA [4], A/J [2-5] and A/HeJ [3], ii) outbred PO [4] and
TO [4]. Also, the wild-derived inbred strains Mus
musculus castaneus (southestern Asian house mouse) and Mus spretus (western
wild mouse) [4].
For new submissions
or enquiries, please contact Dr. Sotiria Boukouvala (sboukouv@mbg.duth.gr).
[1] Hein,
D.W.; Boukouvala, S.; Grant, D.M.; Minchin, R.F. and Sim, E. (2008) Changes
in consensus arylamine N-acetyltransferase
gene nomenclature. Pharmacogenet. Genomics 18(4), 367-368.
[2] Kelly, S.L. and Sim, E. (1994) Arylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitro. Biochem. J. 302(2), 347-353.
[3] Fretland,
A.J.; Doll, M.A.; Gray, K.; Feng, Y. and Hein, D.W. (1997) Cloning,
expression and recombinant expression of
[4] Boukouvala,
S.; Price, N. and Sim, E. (2002) Identification and functional
characterization of novel polymorphisms associated with the genes for arylamine
N-acetyltransferases in mice. Pharmacogenetics 12(5), 385-394.
[5] Estrada-Rodgers, L.; Levy, G.N. and Weber, W.W. (1998) Substrate selectivity of mouse N-acetyltransferase 1, 2, and 3 expressed in COS-1 cells. Drug Metab. Dispos. 26(5), 502-505.
[6] Walraven,
J.M.; Doll, M.A. and Hein, D.W. (2006) Identification and characterization
of functional rat arylamine N-acetyltransferase
3: comparisons with rat arylamine N-acetyltransferases
1 and 2. J. Pharmacol. Exp. Ther. 319(1), 369-375.
[7] Walraven,
J.M.; Barker, D.F.; Doll, M.A. and Hein, D.W. (2007) Tissue expression and
genomic sequences of rat N-acetyltransferases
rNat1, rNat2, rNat3, and
Functional characterization of a novel rNat3*2
genetic variant. Toxicol. Sci. 99(2), 413-421.